Thursday, October 31, 2019

International Finance Management Term Paper Example | Topics and Well Written Essays - 3750 words

International Finance Management - Term Paper Example Forward contracts however can not change hands and are contracts between two parties. Prevailing interest rates in the respective markets have a major impact on the increase or decrease of a contracts price. For example if the GBP/USD contract is on sale at CME, than an increase in the interest rates prevailing in the British economy would increase the contract price and those in the United States economy would decrease it. This is because there is a direct link between the price of value of a currency and interest rates. If for example interest rates are reduced money supply will increase in the economy. According to the economic laws of supply and demand, an increased supply would result in lower prices. Thus the futures expected price of currency would also decrease. Balance of trade is without doubt the most important factor that can affect the price of a currency. Balance of trade refers to the difference between what a country imports and exports. Also called the current account balance, it can only be offset if investors keep investing in dollar dominated assets. If a country gives a budget with a deficit, it can only fill up that deficit by borrowing money for the national or international market. The government will have to use up its currency reserves to pay off international debt and possibly print more money to pay of national debt; these will decrease the value of national currency. The stability of the government is also a huge factor in determining the increase or decrease of national currency value. This is because a stable government establishes stable policies; this stability reduces investor risk thus increasing currency value. These factors have huge impacts on Currency value. This is because the risk associated with the currency is high in war and the risk of default; on foreign payments also increase. In case of Natural disasters, the expenditure of the country increases on

Monday, October 28, 2019

Journal on Poems Essay Example for Free

Journal on Poems Essay The poem portrays the definitions of sanity and madness. However, these definitions vary from the perspective of people and the surroundings as pointed out in the second line. In other words, the poem points out that for certain people, something normal is considered insane and vice versa. 2. The Road Not Taken by Robert Frost Basically, for me, the poem depicted a common experience in life wherein one makes a choice between two things and then wonders what could’ve happened had he or she took the other option. The situation shown in the poem reflects a reality that everyone faces in life which is making a choice and standing by that decision. However, as illustrated in the poem, despite the choices people make regarding, for example, careers and business ventures, there will also be times that one doubts whether he or she made the right decision or not. 3. Design by Robert Frost The poem basically illustrates that most of the time the world’s beauty can be appreciated through observing the natural things such as the spider and the moth. In addition, as the title suggests, life is basically a design. It is natural for a spider to eat the moth as it was designed to do so. However, since the spider killed the moth, the author also wonders why the â€Å"designer† allows such a thing to happen. In short, while the author acknowledges the beauty natural order of things, he also questions why horrible events, such as death, happen. 4. Mending Wall by Robert Frost Initially, the poem suggests that there are no need for walls between neighbors as this suggests division. However, at the end, although the speaker in the poem still did not favor the construction of a wall between him and his neighbor, he acknowledged the fact that walls are important as these set boundaries and limitations. Basically, the poem also illustrates that in real life, â€Å"walls† or boundaries, which are best exemplified by laws and rules, are necessary to maintain order. 5. Cross by Langston Hughes The poem clearly depicts the speaker’s confusion about his identity. As the title of the poem says, the speaker is a â€Å"cross† between a white man and a black woman and is confused about his true identity. He also wonders if he would share the same fate of his mother and father and yearns to know where he really belongs to. The poem also depicts two realities in life which are discrimination and racism. Basically, the poem suggests that if these two did not exist, the speaker would not have to long for acceptance and would not have to search for his identity.

Saturday, October 26, 2019

Effect of Phototherapy on Sleep Disorders

Effect of Phototherapy on Sleep Disorders In the natural world, the light – dark cycle entrains our rhythm. Light is a very effective ‘Zeitgeber’. In the presences of environmental time cues, sleep-wake physiology, and gene expression continue to exhibit a near-24-hour circadian rhythm regulated by the Suprachiasmatic Nucleus in the Hypothalamus. Phototherapy is an accepted modality for non- pharmacological management of Circadian Disorders such as Delayed Sleep Phase Syndrome, Insomnia etc. This review discusses the physiological principle and highlights evidence based literature of phototherapy and its management in Sleep Disorders. Introduction; Living organism’s exhibit a biological periodicity, this rhythm when occurs on a 24 hour cycle is known as ‘Circadian Rhythm’. A rhythmic biological cycle that displays an endogenous entrainable oscillation of less than 24 hours in known as ultradian rhythm. and that last for more than 24 hours is known as Infradian rhythms. Circadian Rhythms generate rhythmic cycling of sleep patterns, food intake, sexual behavior, core body temperature and secretion release of hormones such as ACTH, Prolactin, Gonadotorophin and Melatonin. Circadian Rhythms are generated by the Suprachiasmatic Nucleus (SCN) of the Anterobasal Hypothalamus. Pineal gland regulates the rhythmic production and release of melatonin. The duration, phase and amplitude of melatonin and cortisol secretion, are influenced by changes in light-dark cycles. The plasma levels are low during day time and are high at night. This rhythm is maintained by the SCN and is entrained by the light-dark cycle. Low light intensities like 100 to 500 lux also have been shown to suppressed levels of melatonin. Phototherapy or light therapy utilizes light boxes which are typically LED square bright lights, ranging from 8-12 x 12-24 inches that emit 10,000 Lux (highest Lux) light, cool color temperature light acts as natural sunlight without the harmful effect of UV rays. This mode of entraining the sleep wake cycle is an accepted modality and mainstay treatment in the non-pharmacotherpeutic management of Circadian Rhythm Disorders. Principles of Phototherapy The goal of the Circadian Rhythm is to maintain a bridge between sleep patterns and the internal clock that is set at a optimally synchronized time. This results in a normal sleep-wake pattern. The Biological Model-Phase response curve The Phase Response curve is modulated by two efficacious modalities i.e. light and melatonin, both of which are exploited to entrain the circadian cycle. Bright light is very helpful in synchronizing the human rhythms and the melatonin serves as a ‘‘dark pulse’’ helping to induce night-time behaviors. Bright morning light advances circadian rhythms; bright evening light delays them. Melatonin in the evening advances circadian rhythms; melatonin in the morning delays them. Circadian Disturbances and Insulin Resistance Type 2 Diabetes Mellitus is a multifactorial disorder, of which Circadian Disturbances is one of the lifestyle factors that contribute to it. Sleepdisturbances including sleep insufficiency, sleep loss, sleep fragmentation, are connected to abnormal Glucose Metabolism and thus, increase the risk of Type 2 Diabetes Mellitus. Studies in rodent models suggest that disruption of Circadian Rhythms leads to impaired glucose homeostasis and beta-cell failure, culminating in increased susceptibility to Type 2DM. Disturbed Circadian Rhythm is causative factor in the recent epidemic â€Å"Obesity†. In controlled clinical studies, acute 1-3 week circadian misalignment (alone) or in combination with sleep restriction results in dysregulation of glucose homeostasis and consequent glucose intolerance attributed in part to loss of beta-cell function as well as decline in insulin sensitivity. CIRCADIAN RHYTHM PROBLEM CONTRIBUTES TO INFLAMMATORY DISEASES. Inflammatory bowel disease (IBD), including ulcerative colitis (UC) and Crohns disease (CD), is a chronic and recurrent inflammatory disorder of the intestinal tract. Study says that sleep disturbances are one of the main reasons of pathogenesis of the patients with IBD. In addition melatonin plays a vital role in regulation of inflammation as well as immune system and antioxidant system in the intestinal disorders. (16, 17) CIRCADIAN RHYTHM and visually Impaired Bright light has been shown to suppress Melatonin secretion even in visually impaired subjects which substantiates the fact that non-visual photoreceptors in the eye mediate the Circadian Rhythm regulating effects of light CIRCADIAN RHYTHM AND IMMUNITY Sleep restriction and sleep deficit increase your vulnerability to disease. The immune system is connected to the sleep regulatory system and actions of the immune system to fight disease.Sleep is regulated partly by immune system components called cytokines. Blood counts of T-cells and levels of proinflammatory cytokines are high during the night while leukocytes and the anti-inflammatory cytokine IL-10 go up during daytime. Changes in the immune system seem associated with the onset of narcolepsy, which has a neurological cause (brain cell death) inflammatory diseases increase cytokine levels and make people feel fatigued. This is a good thing during a short-term injury or illness, as it drives the person to rest. For those with chronic inflammation, however, the immune system keeps them tired for long periods, which may explain symptoms of fibromyalgia and chronic fatigue disorder. The trouble in sleeping that people with those conditions experience is not due to just the discomforts of the illnesses, but because the sleep regulation system is affected. The different phases of sleep are responsible for different functions within our bodies. The first and second phases involve settling in, resulting in rhythmic breathing and a lowered body temperature. The third and fourth stages are when our bodies are working to restore themselves. During this time our muscles relax and the blood supply going to them increases. Our bodies use this time to repair tissue damage and grow new tissue. Important hormones are released and our energy is renewed. These stages appear to be a critical factor in maintaining a healthy immune system and any sleep disturbance that impacts them, impacts our health. It is becoming increasingly evident that disruption of daily rhythms, such as from sleep deprivation, affects the immune response. Toll-like receptor 9 (TLR9), is an immune system protein that can sense bacterial and viral DNA Role of Phototherapy Cognitive Impact Light intensity has a direct impact on cognitive performance and alertness and on the subjective feeling of sleepiness. The researchers found that volunteers subjected to higher light intensity during the afternoon were more alert all the way into the early evening than those who were not. But when subjected to light intensity 10 times weaker, they showed signs of sleepiness and obtained lower scores on the memory tests. Artificial light is used to phase shift circadian rhythm and help improve performance, sleep, and well-being during shiftwork simulations , this was proved in study designed for NASA personals during t he prelaunch week. The treated subjects were self exposed to 10, 000 Lux. The treated personnel showed a positive result reporting better sleep, performance, and physical and emotional well-being than control subjects and rated the treatment as highly effective for promoting adjustment to their work schedules for the study. Nocturnal alertness, performance, and daytime sleep could be improved by light exposure of tolerable intensity and duration in a real work place. This was proved in a cross-over design study conducted on 12 night Shift nurses with three different treatment procedures: Room Light (RL) exposure in the night followed by a 1hr sunlight or 10,000 lux light next morning(08:30 to 09:30), Bright Light (BL) a 4-hour nocturnal light exposure of 4,000-6,000 lux (from 01:00 to 05:00) and Bright Light with Sunglasses (BL/S) the same nocturnal light exposure as in BL was done with light attenuation in the morning. Nocturnal alertness was measured by a visual analog scale. Daytime sleep was recorded with actigraphy. Nocturnal alertness was the highest in the BL/S. The improvement was maximized by attenuating morning light. Sun-Downing phenomenon Sundowning is a clinical phenomenon characterized by the emergence or increment of neuropsychiatric symptoms such as confusion, disorientation, anxiety, agitation, aggression, pacing, wandering, resistance to redirect screaming, yelling and so forth observed late afternoon, evening or at night and occurs among cognitively impaired, demented, or institutionalized elderly patients. In a 6-week, double-blind, placebo-controlled, cross-over trial the effects of bright light therapy combined with melatonin on motor restless behavior in demented patients had been evaluated. This study concluded that bright light therapy (10,000 lux bright light) has a positive effect on motor restlessness in subjects with dementia. Mood disturbances Manic-Depressive Illness (MDP): MDP is recurrent illness in which episodes of Mania and Depression occur and remit spontaneously. Several clinical studies say that disturbance in the Circadian Rhythms play a crucial role in its pathophysiology. Melatonin secretion shows abnormal levels in some bipolar patients (MDP). Patients with MDP exhibit circadian sleep wake rhythm in which patients spent one complete sleepless night in between two nights of normal sleep. In a study, 143 patients with a major depressive episode in the course of bipolar disorder (DSM-IV criteria) treatment with 3 consecutive totalsleepdeprivation cycle (each composed of a period of 36 hours awake followed by recovery sleep), light therapy, and lithium rapidly decreased the depressive suicidality and prompt antidepressant response in patients with drug-resistant major depression in the course of bipolar disorder. Borderline personality disorder (BPD) is typically characterized by instability and impaired behaviour , affectivity, interpersonal relations and lifestyle. This open study assessed 13 female patients for the effectiveness of the application of bright light (10,000 lux, 6:30 to 7:30 a.m. for 6 weeks) added to SSRIs in drug-resistant depressed patients with comorbid BPD who did not show any improvement to 6-week administration of antidepressants. The participants were regularly evaluated using the CGI, HAMD and MADRS scales and the BDI and BDI self-report inventories. All the assessments proved that the application of Bright light leads to a significant improvement. SAD: Phototherapy acts through Retinal Melatonin or Rhodopsin, which regulates Dopamine release in the eye where it acts as the main neurotransmitter. The retina-SCNvpineal gland forms a link, which is disturbed in SAD. By suppressing retinal Melatonin, Phototherapy has been suggested to correct the underlying biochemical abnormality seen in SAD and thereby inducing clinical remission.In Non- Demented people, light therapy is an accepted and validated treatment for seasonal affective disorder, but has also been reported to be effective in Non –Seasonal Depression (15). Recently it has been noted that exposure of SAD patients to natural sunlight in the morning hours resulted in complete remission of depressive symptoms. In the study, N=24(12 SAD patients and 12 controls) were exposed to morning light therapy in the winter and the melatonin profiles being sensitive to light were measured before and after treatment. The SAD Patients showed a phase advance of melatonin rhythms in response to phototherapy which showed an association between phase position and phase shift in the SAD patients. This instability may be secondary to impaired serotoninergic function in the afferent pathways to the suprachiasmatic nuclei. This seems to be a significant advancement in the etiology of SAD that links light with Mood Disorders. In Seasonal Affective Disorder (SAD) is common when vitamin D stores are typically low. wavelengths between 280-320 nm which are Broad-spectrum light therapy that allow the skin to produce vitamin D. In a prospective, randomized controlled trial was conducted N=15 subjects with SAD (8 subjects-100,000 I.U. of vitamin D and 7 subjects–phototherapy). At the onset of treatment and after 1 month of therapy subjects different depression scale were administered. Vitamin D status improved in both groups (74% vitamin D group, p ADHD Morning bright light therapy is associated helps reduce both subjective and objective measures of core ADHD pathology, improves mood symptoms, and phase advance in circadian preference. Multiple regressions showed that the shift toward an earlier circadian preference with LT was the strongest predictor of improvement on both subjective and objective ADHD measures. In the Elderly The risk of developing depression increases with old age. The occurrence of a major depressive episode in Alzheimer’s disease is as high as 20-25%and minor depressive symptoms occur in an additional 20-30% (9, 10). In a randomized double-blind placebo-controlled trial, patients with early Alzheimer’s Disease (AD), Mild Cognitive Impairment (MCI) and Subjective Memory Complaints (SMC)(N=79, Age = between 50 75). Patients were exposed to ~10,000 lux for two years, the active condition or ~300 lux in the placebo condition, daily, for two half-hour sessions at fixed times in the morning and evening. Neuropsychological, behavioral, physiological and endocrine measures are assessed at baseline and follow-up every five to six months. The evaluation showed long-term daily bright light prevented worsening of sleep-wake rhythms and depressive symptoms in elderly people with memory complaints. Elderly experience increased difficulties with sleeping, and thus could be one of the contributing factor for mood problems.(11) Factors contributing in Aging process Aging process | | Impaired Ocular light transmission due to age related eye deficiencies | | Requires high demand of light intensities inorder to maintain a sufficient input to SCN | | Diminished SCN input | | Arrhythmia in the Sleep Wake cycle Studies report that it is possible to reactivate the SCN and improve ‘Sleep –Wake Rhythm’ by applying extra light. Light therapy provides a safe treatment option (13).It’s reported that, bright light therapy is decreasing common health issues (14). In 10 Alzheimers patients with sundowning behavior and sleep disturbances were studied for a week who received 2 hours/day of exposure to bright light between 7:00 p.m. and 9:00 p.m. The results showed that the proportion of total daily activity occurring during the nighttime decreased during the light-treatment week. The relative amplitude of the circadian locomotor activity rhythm, a measure of its stability, increased during the light-treatment week. This kind of effect mediated through a chronobiological mechanism. Artificial light is used to phase shift circadian rhythm and help improve performance, sleep, and well-being during shiftwork simulations , this was proved in study designed for NASA personals during t he prelaunch week. The treated subjects were self exposed to 10, 000 Lux. The treated personnel showed a positive result reporting better sleep, performance, and physical and emotional well-being than control subjects and rated the treatment as highly effective for promoting adjustment to their work schedules for the study. In study bright light exposure improved sleep quality in 7-18% subjects, the study consisted of 13 interventional studies with 1154 participants. Jet lag causes distress to the number of travelers impairing sleep, mood and cognitive performance. Timed exposure to bright light and melatonin administration can help to reduce symptoms. Specific recommendations using bright light and melatonin for eastward and westward travel before and after departure are provided for time zone changes of up to 6, 7–9 and 10 or more hours. Timed bright light and melatonin administration, by helping to adjust underlying circadian rhythms to the new time zone, can serve to mitigate the symptoms of jet lag. Reducingthe symptoms of jet lag by this methods can lessen the mood, cognitive and behavioral symptoms resulting from these desynchronized rhythms.(

Thursday, October 24, 2019

Paideia of Nihil of Reliabilty of Existing and Paideia of Nihil of Truth of Being :: Philosophy

Paideia of "Nihil of Reliabilty of Existing" and Paideia of "Nihil of Truth of Being" ABSTRACT: This paper traces the transformation of the idea of Paideia as an intellectual mode of existence and being in Antiquity, the Middle Ages, the Renaissance, and the modern period to the idea of Paideia as an intellectual mode of the nihil that is oriented toward the future. It comments specifically on the ideas of Leibniz and Heidegger which have contributed to this development. Our understanding of Paideia is multiple-valued. One can think about it as about medicine, and as about goodness, and cultivation of justice in the state (governors, guards, citizens, women and children). Paideia practically includes all sides of culture. One can argue up the definition for a long time. Let consider classics.(1) Namely in Greek Platon's Paideia (IV ad.) classical problem of the possibility and borders of different attempts to improve life of the person was put forward. And this happened in conditions, when relations, traditionally seemed stable, between ideas of "Existence" and "Being", "Reliability" and "Truth" and finally of constantly breaking in our life unintelligible ("external" and at the same time "internal") forces, which opens themselves to us as "Nothing" or, in other interpretation, as "Nihil", are changing drastically. Lets try to consider specifics of an inconsistent condition of Paideia at present through a prism of concepts of the end a XX century peo ple about "Nihil – Nothing". What does such a consideration give from the point of view of understanding of possibility somehow to influence on the objective processes of "educating training" and of "training education".(2) The complete name of this article should sound as: "Duality of Leibniz's understanding of "Nihil of Reliability of Existing" in comparison with duality of Heidegger's understanding of "Nihil of Truth of Being" in struggle of philosophical ideas when trying to understand a problem of inconsistency "con-crete" (total specific) "self-development – self-creativity – self-creation" of Paideia "in a whole" "now-and-here" "in this person" today". Understanding of "Nihil of Reliability of Existing" by Leibniz turns to be the representation of understanding "Nihil of Truth of Being" by Heidegger. Understanding of this "Nihil" by the last is only a special case of variety of representations of "Nothing – Nihil" in the deconstructed world of phil osophical thought of our days. I About some preliminary theoretical (conceptual-terminological) remarks, that will allow to specify philosophical aspect of the analysis. It is supposed that the basic concepts are either rather well known, or their development can be found in other work of the author.

Wednesday, October 23, 2019

Life Goes On Essay

Life experiences bring knowledge to people. Having a lot of good and bad experiences helps us improve our way of thinking; it opens our minds and teaches us unforgettable lessons about life, lessons that we have to apply in the future. My parents taught me to be independent and self-motivated by providing me opportunities to learn by trial and error. I was given a remarkable amount of freedom at a young age. When I was 6, my parents bought me an old computer for $25 from a local yard sale with the intention of letting me loose on it . I was thrilled .Motivated by curiosity. I delved into it at once and learned how to use each and every feature of the computer. My intellectual curiosity is the result of a unique combination of early influences and childhood experiences which have fueled my passion for learning inside and outside of the classroom—learning from everything I do . I hope to apply this curiosity to all aspects of my life. I have lived such a life experience in my last high school year. Along with 12th grade and turning up eighteen years old, I was going to become independent, ‘on my own feet’ as some would say. Time has taught me how to take fast decisions. Some of them were bad decisions, some were good. It was a very difficult period for me, as I was forced to fight against time, stress, hidden emotions and most important, I had to choose the road to follow for my career. The final exam was a hard challenge. There were times I felt I would quit; times of weakness when I searched peace in a cigarette without thinking it can make me dependent, all these times I was teaching a great lesson: maturity! I realized I wasn’t a kid anymore and that my own destiny can be influenced by a simple decision. This experience made me learn what truly means making sacrifices for achieving your goals. I gave up to my free time to replace it with hard working, interminable tiredness and meditations. It wasn’t an easy sacrifice, as desperation said her word in some moments. But the most important thing is the positive lesson it taught me, that is, never gives up fighting, no matter what happens because there is a hope for everything in life, and loosing it doesn’t bring you close to your goals. I have lost some of my friends for being able to reach on top, and this thing taught me what true friendship really meant and that some people we see as friends can turn out to be our worst enemies. To me, change is something new and you experience changes throughout your life. However, I learnt that telling everything about yourself can only bring bad things,  because you can never know how a relationship can turn out between people. I can say I found myself again in this last high school year, rediscovered my ambition and passion for the things I do.

Tuesday, October 22, 2019

Difference Between Independent and Dependent Variables

Difference Between Independent and Dependent Variables The two main variables in an experiment are the independent and dependent variable. An independent variable is the variable that is changed or controlled in a scientific experiment to test the effects on the dependent variable. A dependent variable is the variable being tested and measured  in a scientific experiment. The dependent variable is dependent on the independent variable. As the experimenter changes the independent variable, the effect on the dependent variable is observed and recorded. Independent and Dependent Variable Example For example, a scientist wants to see if the brightness of light has any effect on a moth being attracted to the light. The brightness of the light  is controlled by the scientist. This would be the independent variable. How the moth reacts to the different light levels (distance to light source)  would be the dependent variable. How to Tell the Variables Apart The independent and dependent variables may be viewed in terms of cause and effect. If the independent variable is changed, then an effect is seen in the dependent variable. Remember, the values of both variables may change in an experiment and are recorded. The difference is that the value of the independent variable is controlled by the experimenter, while the value of the dependent variable only changes in response to the independent variable. Remembering Variables With DRYMIX When results are plotted in graphs, the convention is to use the independent variable as the x-axis and the dependent variable as the y-axis. The DRY MIX acronym can help keep the variables straight: D is the dependent variableR is the responding variableY is the axis on which the dependent or responding variable is graphed (the vertical axis) M is the manipulated variable or the one that is changed in an experimentI is the independent variableX is the axis on which the independent or manipulated variable is graphed (the horizontal axis) Independent vs Dependent Variable Key Takeaways The independent and dependent variables are the two key variables in a science experiment.The independent variable is the one the experimenter controls. The dependent variable is the variable that changes in response to the independent variable.The two variables may be related by cause and effect. If the independent variable changes, then the dependent variable is affected. Sources Carlson, Robert. A concrete introduction to real analysis. CRC Press, 2006. p.183.Dodge, Y. (2003) The Oxford Dictionary of Statistical Terms, OUP. ISBN 0-19-920613-9Everitt, B. S. (2002). The Cambridge Dictionary of Statistics (2nd ed.). Cambridge UP. ISBN 0-521-81099-X.

Monday, October 21, 2019

Sun Yat-Sen essays

Sun Yat-Sen essays Sun Yat-Sen helped the growth of Nationalism during the early 20th century. After experiencing and studying in Hawaii, he got a taste of what the western world was like. Sun wanted to help westernize China to keep up with the worlds technology and economy. His goal was to nationalize China. He also wanted to aid in reforming the social problems China was facing. He started groups to revolutionize China and overthrow the rule of the Qing dynasty. Sun Yat-Sen traveled all over the world to hide from the officials of the Qing dynasty and to gain funds for his Chinese Revolutionary Army. In 1911, the revolution occurred and Sun became the president of The Republic of China. He was mainly interested in, integrating ethnic minorities, enhancing welfare needs of the poor, promoting womens rights, and opposing the archaic practice of footbinding. Yet, Sun was unsuccessful with his dreams for China, he did some writing for a democratic, government. He had three principles that he wanted his followers to carry on after he died. The three principles consisted of Nationalism, Democracy, and Livelihood. Sun was important in the 20th century for his work in trying to incorporate colonialism and imperialism in his China. Suns plans were implemented in Taiwan and credit was given to him for his three principles. Though it was not implemented in China, China is now considering applying Suns three principles to unify China. ...